Our complete brain nutrition formula, Remind® delivers a unique dietary array of nutrients to support optimal memory function, boost mental well-being and promote overall brain function. This unique formula contains potent servings of pyroglutamic acid, and DMAE.
Pyroglutamic acid is known to support memory and communication between both lobes of the brain, while DMAE helps maintain mental focus and clarity of thought. Add the properties of choline, carnitine and phenylalanine for a Remind® formula you won't soon forget.
Choline is an essential nutrient that is widely distributed in foods, principally in the form of phosphatidylcholine but also as free choline. It is also found in foods in the form of the phospholipid sphingomyelin. Choline is necessary for the structure and function of all cells and is crucial for sustaining life.
Choline plays many roles in the body. The three major metabolic functions of choline are as a precursor for phosphatidylcholine biosynthesis, as a precursor for acetylcholine biosynthesis and as a methyl donor. In addition to serving as a precursor for phosphatidylcholine, choline is the precursor of the phospholipid sphingomyelin. Phosphatidylcholine and sphingomyelin are structural components of biological membranes. These phospholipids also serve as precursors for the intracellular messengers ceramide and diacylglycerol. Choline is also the precursor of the signaling lipids, platelet-activating factor (PAF) and sphingosylphosphoryl-choline.
An association between a low-choline diet and fatty infiltration of the liver in rats was first reported in 1935. Choline, as well as other substances, such as methionine, folic acid and vitamin B12, that prevent deposition of fat in the liver are known as lipotropes. The primary criterion used to estimate the Adequate Intake (AI) for choline is the prevention of liver damage as assessed by measuring serum levels of the liver enzyme alanine aminotransferase or ALT. ALT was formerly called and is still referred to as SGPT (serum glutamate pyrutate transaminase).
The foods richest in phosphatidylcholine, the major delivery form of choline, are beef liver, egg yolks and soya. Beef liver, iceberg lettuce, peanut butter, peanuts and cauliflower are some foods that contain free choline.
Choline is also known as 2-Hydroxy-N,N,N-trimethylethanaminum; (beta-hydroxyethyl) trimethylammonium and bilineurine. The major commercial salts for supplementation are choline chloride and choline bitartrate.
The major pathway for phosphatidylcholine synthesis in the body utilizes preformed or dietary choline. In an alternative pathway for phosphatidylcholine biosynthesis, phosphatidylcholine is sequentially methylated to form phosphatidylcholine, using S-adenosylmethionine as the methyl donor. This is probably the only pathway for de novo synthesis of choline in the body.
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